Protein linked to chronic heart failure: Researchers

May 30, 2017
heart disease ISLAMABAD: Researchers have found a receptor protein on the surface of heart cells that promotes chronic heart failure. The findings suggest that inhibiting this protein could help treat a disease that affects more than 20 million people worldwide, Health News reported. Chronic heart failure is caused by a variety of conditions that damage the heart, including coronary heart disease, hypertension and diabetes. Although the heart initially tries to compensate for this damage and maintain its function by, for example, growing larger, cardiac function gradually declines until the heart is no longer able to pump enough blood and oxygen around the body. A team of researchers led by Mikito Takefuji from Nagoya University School of Medicine discovered that a signalling protein called corticotropin releasing hormone receptor 2 (Crhr2) is expressed on the surface of heart muscle cells, or cardiomyocytes, and that Crhr2 levels increase in mice suffering from heart failure. "Our results suggest that constitutive Crhr2 activation causes cardiac dysfunction and that Crhr2 blockade could be a promising therapeutic strategy for patients with chronic heart failure," Takefuji said. --APP



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